Bus Tickets from Boston, MA, US to Santa Ana, US

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TodayAug 30
from US$280
TomorrowAug 31
MonSep 1
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Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 30 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: September 2 at
    Destination city: Santa Ana
    Destination location: Santa Ana Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 30 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: September 2 at
    Destination city: Santa Ana
    Destination location: Santa Ana Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 30 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: September 2 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 30 at
    Departure city: Boston
    Departure location: Brookline
    Arrival time: September 3 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 30 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: September 2 at
    Destination city: Santa Ana
    Destination location: Santa Ana Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Boston, MA, US to Santa Ana, US: Trip Overview

Average Ticket PriceUS$337
Average Bus Trip Duration3d 8h
Number of daily buses12
Earliest bus departure1:30am
Distance4147 km
Latest bus departure8:55pm

Boston to Santa Ana Bus

With Busbud, comparing and booking tickets for a bus from Boston to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Boston to Santa Ana from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Boston, MA, US - Santa Ana, US

  1. What is the distance between Boston and Santa Ana?

    The distance between Boston and Santa Ana is around 4159 km (2579 miles).

  2. What are the departure and arrival locations for buses traveling from Boston to Santa Ana?

    Buses traveling this route start their trip at Back Bay Station, in Boston, and end it at Santa Ana Greyhound Bus Station, in Santa Ana.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-28
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08-29
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Today
US$272
08-31
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busbud logoThe cheapest trip from Boston, MA, US to Santa Ana, US was searched and found on Aug 30, 2025 with a price of US$272

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Santa Ana, US, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Boston to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Boston to Santa Ana, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Santa Ana.

Tune out to the fine sounds of your best music playlist on your bus trip from Boston to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Boston, MA, US by bus?

Bus from Santa Ana, US to Boston, MA, US

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