Find coaches from Boston, MA, US to Santa Ana, US

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Previously seen journeys

One passenger / one way

  • Departure time: 26 July at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: 29 July at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 26 July at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: 29 July at
    Destination city: Santa Ana
    Destination location: Santa Ana Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 26 July at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: 29 July at
    Destination city: Santa Ana
    Destination location: UC Irvine (Crawford Hall)
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: 26 July at
    Departure city: Boston
    Departure location: Brookline
    Arrival time: 30 July at
    Destination city: Santa Ana
    Destination location: Santa Ana Bus Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: 26 July at
    Departure city: Boston
    Departure location: Brookline
    Arrival time: 30 July at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:

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Bus Boston, MA, US to Santa Ana, US: Trip Overview

Average ticket priceUS$337
Average bus trip duration3d 8h
Number of daily buses12
Earliest bus departure01:30
Distance2572 miles
Latest bus departure20:55

Boston to Santa Ana Bus

With Busbud, comparing and booking tickets for a bus from Boston to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Boston to Santa Ana from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Boston, MA, US - Santa Ana, US

  1. What's the distance between Boston and Santa Ana by coach?

    The distance between Boston and Santa Ana by coach is approximately 2579 miles (4159 km).

  2. What is the best way to go from Boston to Santa Ana without flying?

    You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/08
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29/08
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Today
US$272
31/08
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01/09
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02/09
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03/09
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busbud logoThe cheapest trip from Boston, MA, US to Santa Ana, US was searched and found on 30 Aug 2025 with a price of US$272

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Santa Ana, US as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Boston to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Boston to Santa Ana, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Santa Ana.

Tune out to the fine sounds of your best music playlist on your bus trip from Boston to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Boston, MA, US by bus?

Bus from Santa Ana, US to Boston, MA, US

Why choose Busbud?

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