Bus Tickets from Boston, MA, US to Winston-Salem

Next departures

Next departures for Boston to Winston-Salem on August 29
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Boston (South Station)
Winston Salem Greyhound Bus StationCheapest
FlixBus + Greyhound Lines, Inc.
Brookline
Winston Salem Greyhound Bus StationFastest
Greyhound Lines, Inc.
Boston (South Station)
Winston Salem Greyhound Bus StationNo tags
FlixBus + Greyhound Lines, Inc.
Boston (South Station)
Winston Salem Greyhound Bus StationNo tags
FlixBus + Greyhound Lines, Inc.
Brookline
Winston Salem Greyhound Bus StationNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Boston to Winston-Salem.

Bus
Average Price$75 - $179Average Duration21h 30m
26kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$131 - $192Average Duration1d 1h
94kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Boston to Winston-Salem

Among the sustainable travel choices, the bus stands out as the good way to reach Winston-Salem. The journey takes about 21 hours 30 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.

6bus per day
21h 30mAverage Duration
$75Cheapest ticket
26kgCO₂ emissions

Bus Boston, MA, US to Winston-Salem: Trip Overview

Average ticket price$121
Average bus trip duration21h 30m
Number of daily buses6
Earliest bus departure1:30am
Distance650 miles (1047 km)
Latest bus departure10:00pm

Boston to Winston-Salem Bus

Busbud helps you find a bus from Boston to Winston-Salem. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Boston to Winston-Salem from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Winston-Salem from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Boston, MA, US - Winston-Salem

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/27
$67
08/28
No data
Today
$107
08/30
No data
08/31
No data
09/01
No data
09/02
No data
09/03
No data
busbud logoThe cheapest trip from Boston, MA, US to Winston-Salem was searched and found on Aug 27, 2025 with a price of $67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Winston-Salem, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Boston and Winston-Salem!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Boston to Winston-Salem, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Winston-Salem.

Make a music playlist for your bus ride from Boston to Winston-Salem, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Boston, MA, US to Winston-Salem?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Boston, MA, US by bus?

Bus from Winston-Salem to Boston, MA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Boston

Buses Leaving from Boston

Buses Going to Boston

Popular Buses Connecting Winston-Salem

Buses Leaving from Winston-Salem

Buses Going to Winston-Salem