Find coaches from Gainesville, FL to Greenville, SC

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Previously seen journeys

One passenger / one way

  • Departure time: 5 November at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: 5 November at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: 5 November at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: 6 November at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 5 November at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: 6 November at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 5 November at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: 6 November at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: 5 November at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: 6 November at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:

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Bus Gainesville, FL to Greenville, SC: Trip Overview

Average ticket priceUS$67
Average bus trip duration12h 20m
Number of daily buses5
Earliest bus departure01:10
Distance358 miles
Latest bus departure18:05

Gainesville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Greenville.

From cheap bus tickets to more luxurious buses travelling from Gainesville to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Gainesville, FL - Greenville, SC

  1. What's the distance between Gainesville and Greenville by coach?

    The distance between Gainesville and Greenville by coach is approximately 359 miles (579 km).

  2. How can I travel from Gainesville to Greenville avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/08
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Today
US$68
01/09
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busbud logoThe cheapest trip from Gainesville, FL to Greenville, SC was searched and found on 31 Aug 2025 with a price of US$68

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Greenville, SC as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Gainesville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Gainesville to Greenville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Gainesville to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Gainesville to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Gainesville, FL by bus?

Bus from Greenville, SC to Gainesville, FL

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