Bus Tickets from Buffalo, NY to Florence, SC, US

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TodayAug 29
from US$203
TomorrowAug 30
SunAug 31
MonSep 1
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Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 29 at
    Departure city: Buffalo
    Departure location: Buffalo (BUF) Airport
    Arrival time: August 31 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 29 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: August 31 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 29 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: August 31 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Buffalo to Florence

Bus
Average PriceUS$182 - US$301Average Duration1d 4h
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$241 - US$433Average Duration22h 35m
88kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Buffalo to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 22 hours 35 minutes, and with fares starting at just US$241, it presents an excellent value for a comfortable ride.

2train per day
22h 35mAverage Duration
US$241Cheapest ticket
88kgCO₂ emissions

Bus Buffalo, NY to Florence, SC, US: Trip Overview

Average Ticket PriceUS$209
Average Bus Trip Duration1d 4h
Number of daily buses4
Earliest bus departure12:55am
Distance977 km
Latest bus departure11:59pm

Buffalo to Florence Bus

Busbud helps you find a bus from Buffalo to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Buffalo to Florence will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Buffalo to Florence, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Buffalo, NY - Florence, SC, US

  1. How far is Buffalo from Florence?

    The distance covered from Buffalo to Florence is 969 km (601 miles).

  2. What are the departure and arrival locations for buses traveling from Buffalo to Florence?

    Buses traveling this route start their trip at Buffalo Airport, in Buffalo, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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08-28
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Today
US$195
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08-31
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busbud logoThe cheapest trip from Buffalo, NY to Florence, SC, US was searched and found on Aug 29, 2025 with a price of US$195

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Florence, SC, US, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and Florence!

Much more than a mere vehicle taking you from Buffalo to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to Florence that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Buffalo to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Buffalo, NY to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Buffalo, NY by bus?

Bus from Florence, SC, US to Buffalo, NY

You can also go to Florence, SC, US by train

Train from Buffalo, NY to Florence, SC, US

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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