Bus Tickets from Orlando to Florence, SC, US

Next departures

Next departures for Orlando to Florence on August 25
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Orlando Bus Station
Bus stationCheapest
FlixBus
Orlando Bus Station
Florence, SCFastest
FlixBus
Orlando Bus Station
Bus stationNo tags
FlixBus
Orlando Bus Station
Florence, SCNo tags
FlixBus
The Florida Mall
Florence, SCNo tags

Accepted payments

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Compare 2 ways to go from Orlando to Florence

Bus
Average PriceUS$78 - US$165Average Duration10h 20m
16kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average PriceUS$64 - US$480Average Duration9h 46m
59kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the bus from Orlando to Florence

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 10 hours 20 minutes, and with fares starting at just US$78, it presents an excellent value for a comfortable ride.

3bus per day
10h 20mAverage Duration
US$78Cheapest ticket
16kgCO₂ emissions

Bus Orlando to Florence, SC, US: Trip Overview

Average Ticket PriceUS$85
Average Bus Trip Duration10h 20m
Number of daily buses3
Earliest bus departure4:00am
Distance647 km
Latest bus departure3:40pm

Orlando to Florence Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Orlando to Florence.

We make sure you can find a bus service from Orlando to Florence from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Orlando to Florence, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Orlando - Florence, SC, US

  1. How far is Orlando from Florence?

    It's about 653 km (405 miles) from Orlando to Florence.

  2. What are the departure and arrival locations for buses traveling from Orlando to Florence?

    Buses departing from Orlando Bus Station in Orlando will take you to Florence Bus Station in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-20
No data
08-21
US$70
Today
US$84
08-23
No data
08-24
No data
08-25
US$70
08-26
US$66
08-27
US$70
busbud logoThe cheapest trip from Orlando to Florence, SC, US was searched and found on Aug 26, 2025 with a price of US$66

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Florence, SC, US, as early as possible.

You can expect to pay from US$66 to US$129 for a bus ticket from Orlando to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$66 which is on 2025-08-26.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Orlando to Florence but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Orlando to Florence, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Orlando to Florence that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Orlando to Florence.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Orlando to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Orlando by bus?

Bus from Florence, SC, US to Orlando

You can also go to Florence, SC, US by train

Train from Orlando to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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