Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Charleston Station | Depew Station | CheapestFastest | |||||
| Charleston Station | Exchange Street Station | No tags | |||||
| Charleston Station | Exchange Street Station | No tags | |||||
| Charleston Station | Exchange Street Station | No tags | |||||
| Charleston Station | Depew Station | No tags |
Accepted payments
Compare 2 ways to go from Charleston to Buffalo.
Busbud recommends taking the bus from Charleston to BuffaloAmong the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 1 day, 3 hours 55 minutes and with fares starting at just $177, it presents an excellent value for a comfortable ride.
Train Charleston, SC, US to Buffalo, NY: Trip Overview
Please note, this information is subject to change.
Train Companies
Based on 5434 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $245
Charleston to Buffalo Train
Busbud helps you find a train from Charleston to Buffalo. Get the best fare and schedule, book a round trip ticket or find trains with WiFi and electrical outlets.
We make it our job to connect you with the most dependable companies that offer train service from Charleston to Buffalo.
Discover how much the train trip from Charleston to Buffalo will cost you. Use our filters and sorting features to find the cheapest train tickets or high-end trains.
Frequently asked questions for your trip Charleston, SC, US - Buffalo, NY
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Charleston, SC, US to Buffalo, NY was searched and found on Sep 4, 2025 with a price of $235To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Charleston, SC, US to Buffalo, NY, as early as possible.
You can expect to pay from $235 to $1,985 for a train ticket from Charleston, SC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $235 which is on 2025-09-04.
About Train Travel
Train Travel Tips
There are many train stations in the world, check it station pages on Busbud to get all information you need.
Whether you take a regional or high-speed train to Buffalo, you’ll help reduce the environmental impact and carbon footprint of your trip. As you watch the landscapes unfold before your eyes, you can tell yourself that with this choice, you are making sure they remain protected.
With up to 30x less CO2 emissions for your train journey between Charleston and Buffalo, the train is an ecological alternative to flights or personal cars.
Create your own real life musical score by curating a personalized train travel playlist - the perfect accompaniment to your bus ride from Charleston to Buffalo.
Did you know?
The longest train journey in the world is between Europe and Asia. This long journey starts from Porto in Portugal and crosses the whole European continent to reach Hanoi in Vietnam in 12 days while traveling more than 17,000 km.
Railway companies played a major role as early as 1883 in the use of time zones as we know them today.
One of the deepest train stations in the world is in Kiev. Located at a depth of 105 m, it was designed in this way to serve as a shelter in the event of an attack. The second deepest station is in China. Badaling station is located 60 m under the Great Wall of China!
Top Traveled Train Routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
People from around the world trust Busbud
Popular Trains Connecting Charleston
Trains Leaving from Charleston
Popular Trains Connecting Buffalo
Trains Going to Buffalo
Popular train trips
Top Routes Worldwide
- Train from Wells to Fargo
- Train from Columbia to New York City
- Train from Detroit to Red Wing
- Train from Holland to Taylor
- Train from Los Angeles to Glendale
- Train from Waterloo to Buffalo
- Train from Washington to Leavenworth
- Train from Niagara Falls to Ontario
- Train from Washington to Everett
- Train from Buffalo to New York City
- Train from Seattle to Washington
- Train from Rochester to New York City
- Train from Ventura to Simi Valley
- Train from Fayetteville to Cumberland
- Train from Newark to Essex