Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Syracuse bus station | Terminal Bus Palermo | Cheapest | |||||
| Syracuse bus station | Palermo Oreto Orsi | Fastest | |||||
| Syracuse bus station | Terminal Bus Palermo | No tags | |||||
 | Terminal Interbus | Terminal Bus Palermo | No tags | |||||
| Syracuse bus station | Terminal Bus Palermo | No tags |
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Compare 3 ways to go from Syracuse to Palermo.
Busbud recommends carpooling from Syracuse to PalermoAmong the sustainable travel choices, the carpool stands out as the good way to reach Palermo. The journey takes about 3 hours and with fares starting at just $15, it presents an excellent value for a comfortable ride.
Bus Syracuse to Palermo: Trip Overview
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Syracuse to Palermo Bus
With Busbud, comparing and booking tickets for a bus from Syracuse to Palermo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Syracuse to Palermo.
From cheap bus tickets to more luxurious buses traveling from Syracuse to Palermo, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Syracuse and Palermo?
Frequently asked questions for your trip Syracuse - Palermo
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse to Palermo was searched and found on Aug 27, 2025 with a price of $19To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse to Palermo, as early as possible.
You can expect to pay from $19 to $62 for a bus ticket from Syracuse to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at $19 which is on 2025-08-27.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Syracuse to Palermo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Syracuse to Palermo.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Syracuse to Palermo that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Syracuse to Palermo, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
What's the cheapest way to go from Syracuse to Palermo?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting Syracuse
Buses Leaving from Syracuse
- Bus from Syracuse to Florence
- Bus Syracuse - Taormina
- Syracuse - Agrigento
- Bus from Syracuse to Palermo
- Bus Syracuse - Paris
- Syracuse - Noto
- Bus from Syracuse to Avola
- Bus Syracuse - Messina
- Syracuse - Trapani
- Bus from Syracuse to Rome
- Bus Syracuse - Pachino
- Syracuse - Cassibile
- Bus from Syracuse to Giardini Naxos
- Bus Syracuse - Pescara
- Syracuse - Portopalo di Capo Passero
Buses Going to Syracuse
- Bus from Noto to Syracuse
- Bus Palermo - Syracuse
- Taormina - Syracuse
- Bus from Paris to Syracuse
- Bus Giardini Naxos - Syracuse
- Pachino - Syracuse
- Bus from Avola to Syracuse
- Bus Trapani - Syracuse
- Rome - Syracuse
- Bus from Messina to Syracuse
- Bus Portopalo di Capo Passero - Syracuse
- Rosolini - Syracuse
- Bus from Ancona to Syracuse
- Bus Bari - Syracuse
- Letojanni - Syracuse
Popular Buses Connecting Palermo
Buses Leaving from Palermo
- Bus from Palermo to Frosinone
- Bus Palermo - Porto
- Palermo - Modena
- Bus from Palermo to Maglie
- Bus Palermo - Amsterdam
- Palermo - Parma
- Bus from Palermo to Syracuse
- Bus Palermo - Marsala
- Palermo - Rome
- Bus from Palermo to Alcamo
- Bus Palermo - Terrasini
- Palermo - Mazara del Vallo
- Bus from Palermo to Castelvetrano
- Bus Palermo - Milano
- Palermo - Salemi
Buses Going to Palermo
- Bus from Cosenza to Palermo
- Bus Frosinone - Palermo
- Brescia - Palermo
- Bus from Bari to Palermo
- Bus Modena - Palermo
- Outlet - Palermo
- Bus from Syracuse to Palermo
- Bus Terrasini - Palermo
- Marsala - Palermo
- Bus from Rome to Palermo
- Bus Alcamo - Palermo
- Mazara del Vallo - Palermo
- Bus from Messina to Palermo
- Bus Gela - Palermo
- Naples - Palermo
Popular routes in this country
- Bus from Bari to Matera
- Bus Catania - Syracuse
- Palermo - Trapani
- Bus from Milano to Bergamo
- Bus Venice - Cortina d'Ampezzo
- Bergamo - Milano
- Bus from Taormina to Catania
- Bus Naples - Rome
- Bologna - Florence
- Bus from Rome to Milano
- Bus Trapani - Palermo
- Florence - Rome
- Bus from Matera to Bari
- Bus Syracuse - Catania
- Rome - Venice