Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Roanoke Bus Stop | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Roanoke Bus Stop | 537-517 W. Jackson Blvd | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Roanoke Bus Stop | Downtown Greyhound Station | No tags | ||||
| Bus | Roanoke Bus Stop | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Roanoke Bus Stop | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Today at 10:44 AM EDT.
Compare 2 ways to go from Roanoke to Chicago
Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 22 hours and with fares starting at just $100, it presents an excellent value for a comfortable ride.
Where are the popular stops in Roanoke and Chicago?
Stops in Roanoke
- AExit 140 (Park and Ride), Virginia 24153, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Roanoke to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Roanoke to Chicago?
The cheapest bus tickets from Roanoke to Chicago start from $100. The average price for this route is around $146. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Roanoke to Chicago?
The average bus trip duration from Roanoke to Chicago is 22h, covering a distance of 515 miles (830 km). The quickest bus can get you there in 20h 10m and is operated by Greyhound.
Which bus companies service the Roanoke to Chicago route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Roanoke to Chicago?
The earliest bus departs from Roanoke to Chicago at 4:35am. And the latest bus departs at 12:50pm.
What are the CO₂ emissions for the bus trip from Roanoke to Chicago?
A bus trip from Roanoke to Chicago generates an estimated 20.742900000000002 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Chicago was searched and found on May 14, 2026 with a price of $105To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Chicago, as early as possible.
You can expect to pay from $105 to $247 for a bus ticket from Roanoke to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $132 which is on 2026-05-18.
What's the cheapest way to go from Roanoke to Chicago?
The Bus is the cheapest travel choice for this destination
