Bus Tickets from Panama City, US to Louisville

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TodaySep 1
TomorrowSep 2
from $131
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Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: September 2 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: September 3 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: September 3 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: September 4 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Panama City, US to Louisville: Trip Overview

Average ticket price$120
Average bus trip duration20h
Number of daily buses3
Earliest bus departure7:40am
Distance556 miles (896 km)
Latest bus departure9:10pm

Panama City to Louisville Bus

Busbud helps you find a bus from Panama City to Louisville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Panama City to Louisville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Panama City to Louisville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Panama City, US - Louisville

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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08/31
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Today
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09/02
$123
09/03
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busbud logoThe cheapest trip from Panama City, US to Louisville was searched and found on Sep 2, 2025 with a price of $123

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Louisville, as early as possible.

You can expect to pay from $123 to $130 for a bus ticket from Panama City, US to Louisville based on the last 2 days. You can expect to find the cheapest price for the trip at $123 which is on 2025-09-02.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Louisville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Louisville, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Panama City to Louisville will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Panama City to Louisville while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Panama City, US by bus?

Bus from Louisville to Panama City, US

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