Bus Tickets from Panama City, US to Lake City

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Previously seen trips

One passenger / one way

  • Departure time: October 3 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: October 3 at
    Destination city: Lake City
    Destination location: Lake City Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: August 29 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: August 29 at
    Destination city: Lake City
    Destination location: Lake City Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: August 29 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: August 29 at
    Destination city: Lake City
    Destination location: Lake City Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Bus Panama City, US to Lake City: Trip Overview

Average ticket price$57
Average bus trip duration5h 25m
Number of daily buses1
Earliest bus departure7:40am
Distance187 miles (301 km)
Latest bus departure12:50pm

Panama City to Lake City Bus

Busbud helps you find a bus from Panama City to Lake City. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Panama City to Lake City from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Panama City to Lake City, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Panama City, US - Lake City

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/28
$69
08/29
$36
Today
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08/31
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09/01
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09/02
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09/04
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busbud logoThe cheapest trip from Panama City, US to Lake City was searched and found on Aug 29, 2025 with a price of $36

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Lake City, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Lake City!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Lake City, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Panama City to Lake City that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Lake City.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Panama City, US by bus?

Bus from Lake City to Panama City, US

Why choose Busbud?

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