Bus Tickets from Indianapolis to Spartanburg

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TodaySep 2
TomorrowSep 3
ThuSep 4
FriSep 5
from $75
SatSep 6
SunSep 7
MonSep 8
TueSep 9

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 5 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 6 at
    Destination city: Spartanburg
    Destination location: Spartanburg
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 5 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 6 at
    Destination city: Spartanburg
    Destination location: Spartanburg
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 5 at
    Destination city: Spartanburg
    Destination location: Spartanburg
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 6 at
    Destination city: Spartanburg
    Destination location: Spartanburg
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: September 6 at
    Destination city: Spartanburg
    Destination location: Spartanburg
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from Indianapolis to Spartanburg.

Bus
Average Price$67 - $212Average Duration20h 55m
16kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$133 - $233Average Duration1d 4h
59kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Spartanburg

Among the sustainable travel choices, the bus stands out as the good way to reach Spartanburg. The journey takes about 20 hours 55 minutes and with fares starting at just $67, it presents an excellent value for a comfortable ride.

7bus per day
20h 55mAverage Duration
$67Cheapest ticket
16kgCO₂ emissions

Bus Indianapolis to Spartanburg: Trip Overview

Average ticket price$80
Average bus trip duration20h 55m
Number of daily buses7
Earliest bus departure3:35am
Distance400 miles (644 km)
Latest bus departure11:30pm

Indianapolis to Spartanburg Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Spartanburg is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to Spartanburg from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Indianapolis to Spartanburg, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Indianapolis - Spartanburg

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
$117
09/01
No data
Today
No data
09/03
$67
09/04
No data
09/05
$68
09/06
No data
09/07
$96
busbud logoThe cheapest trip from Indianapolis to Spartanburg was searched and found on Sep 3, 2025 with a price of $67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Spartanburg, as early as possible.

You can expect to pay from $67 to $202 for a bus ticket from Indianapolis to Spartanburg based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-09-03.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Indianapolis to Spartanburg.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Spartanburg, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Indianapolis to Spartanburg that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Indianapolis to Spartanburg, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from Indianapolis to Spartanburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Spartanburg to Indianapolis

You can also go to Spartanburg by train

Train from Indianapolis to Spartanburg

Why choose Busbud?

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