Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Indianapolis Bus Station | Florence, SC | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | Downtown Transit Center | Florence, SC | Fastest | |||||
 | Greyhound Amtrak Station | Florence Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Indianapolis Bus Station | Florence, SC | No tags | |||||
 | Downtown Transit Center | Florence, SC | No tags |
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Bus Indianapolis to Florence, SC, US: Trip Overview
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Indianapolis to Florence Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Indianapolis to Florence.
We make sure you can find a bus service from Indianapolis to Florence from the most reliable bus companies operating this trip.
Discover how much the bus trip from Indianapolis to Florence will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Indianapolis and Florence?
Frequently asked questions for your trip Indianapolis - Florence, SC, US
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Florence, SC, US was searched and found on Aug 31, 2025 with a price of $188To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Florence, SC, US, as early as possible.
You can expect to pay from $188 to $1,289 for a bus ticket from Indianapolis to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $188 which is on 2025-08-31.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Indianapolis to Florence but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Florence, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Indianapolis to Florence will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Indianapolis to Florence, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Top traveled bus routes
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