Bus Tickets from Houston, US to Santa Ana, US

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TodayAug 28
TomorrowAug 29
SatAug 30
SunAug 31
from $146
MonSep 1
TueSep 2
WedSep 3
ThuSep 4

Cheap buses leaving Sunday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 31 at
    Departure city: Houston
    Departure location: Houston Bus Station
    Arrival time: September 1 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 31 at
    Departure city: Houston
    Departure location: Houston Bus Station
    Arrival time: September 1 at
    Destination city: Santa Ana
    Destination location: Santa Ana Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 31 at
    Departure city: Houston
    Departure location: Houston Bus Station
    Arrival time: September 1 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 31 at
    Departure city: Houston
    Departure location: Houston Bus Station
    Arrival time: September 1 at
    Destination city: Santa Ana
    Destination location: UC Irvine (Crawford Hall)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 31 at
    Departure city: Houston
    Departure location: Downtown Gray & Smith
    Arrival time: September 2 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: FlixBus + Greyhound Lines Mexico + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines Mexico + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Houston, US to Santa Ana, US: Trip Overview

Average ticket price$190
Average bus trip duration1d 16h
Number of daily buses22
Earliest bus departure2:00am
Distance1350 miles (2177 km)
Latest bus departure11:20pm

Houston to Santa Ana Bus

Busbud helps you find a bus from Houston to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Houston to Santa Ana will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Houston to Santa Ana, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Houston, US - Santa Ana, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/26
$305
08/27
$258
Today
No data
08/29
No data
08/30
No data
08/31
$139
09/01
$166
09/02
No data
busbud logoThe cheapest trip from Houston, US to Santa Ana, US was searched and found on Aug 31, 2025 with a price of $139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Houston, US to Santa Ana, US, as early as possible.

You can expect to pay from $139 to $320 for a bus ticket from Houston, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2025-08-31.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Houston and Santa Ana!

Much more than a mere vehicle taking you from Houston to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Houston to Santa Ana that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Houston to Santa Ana, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Houston, US by bus?

Bus from Santa Ana, US to Houston, US

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