Bus Tickets from Greenville, SC to Gainesville, FL

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Previously seen trips

One passenger / one way

  • Departure time: September 6 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 7 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 20 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 21 at
    Destination city: Gainesville
    Destination location: Gainesville Bus Stop
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: October 3 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: October 3 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: October 3 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: October 3 at
    Destination city: Gainesville
    Destination location: Gainesville Bus Stop
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: October 3 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: October 4 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:

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Compare 2 ways to go from Greenville to Gainesville.

Bus
Average Price$58 - $279Average Duration16h 30m
14kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$175 - $175Average Duration1d 6h
52kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Greenville to Gainesville

Among the sustainable travel choices, the bus stands out as the good way to reach Gainesville. The journey takes about 16 hours 30 minutes and with fares starting at just $58, it presents an excellent value for a comfortable ride.

9bus per day
16h 30mAverage Duration
$58Cheapest ticket
14kgCO₂ emissions

Bus Greenville, SC to Gainesville, FL: Trip Overview

Average ticket price$99
Average bus trip duration16h 30m
Number of daily buses9
Earliest bus departure11:15am
Distance353 miles (569 km)
Latest bus departure10:00pm

Greenville to Gainesville Bus

With Busbud, comparing and booking tickets for a bus from Greenville to Gainesville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Greenville to Gainesville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Greenville to Gainesville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Greenville, SC - Gainesville, FL

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/30
$96
08/31
$81
Today
No data
09/02
No data
09/03
No data
09/04
$60
09/05
No data
09/06
No data
busbud logoThe cheapest trip from Greenville, SC to Gainesville, FL was searched and found on Sep 4, 2025 with a price of $60

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Gainesville, FL, as early as possible.

You can expect to pay from $60 to $265 for a bus ticket from Greenville, SC to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $60 which is on 2025-09-04.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Greenville to Gainesville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Greenville to Gainesville, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Gainesville will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Greenville to Gainesville while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

What's the cheapest way to go from Greenville, SC to Gainesville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Gainesville, FL to Greenville, SC

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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