Bus Tickets from Florence, SC, US to Buffalo, NY

Next departures

Next departures for Florence to Buffalo on August 31
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Florence, SC
Buffalo (BUF) AirportCheapest
FlixBus
Florence, SC
Buffalo (BUF) AirportFastest
FlixBus + Greyhound Lines, Inc.
Bus station
Niagara Frontier Transportation AuthorityNo tags
FlixBus
Florence, SC
Niagara Frontier Transportation AuthorityNo tags
FlixBus + Greyhound Lines, Inc.
Bus station
Buffalo (BUF) AirportNo tags

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Compare 2 ways to go from Florence to Buffalo.

Bus
Average Price$168 - $382Average Duration1d 1h
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$264 - $433Average Duration22h 30m
88kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Florence to Buffalo

Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 1 day, 1 hour 10 minutes and with fares starting at just $168, it presents an excellent value for a comfortable ride.

5bus per day
1d 1hAverage Duration
$168Cheapest ticket
24kgCO₂ emissions

Bus Florence, SC, US to Buffalo, NY: Trip Overview

Average ticket price$205
Average bus trip duration1d 1h
Number of daily buses5
Earliest bus departure12:05am
Distance606 miles (976 km)
Latest bus departure4:15pm

Florence to Buffalo Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Buffalo.

We make it our job to connect you with the most dependable bus companies that cover bus service from Florence to Buffalo.

Whether it is cheap bus tickets or more luxurious buses going to Buffalo from Florence, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Florence, SC, US - Buffalo, NY

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/27
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08/28
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Today
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08/30
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08/31
$169
09/01
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09/02
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09/03
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busbud logoThe cheapest trip from Florence, SC, US to Buffalo, NY was searched and found on Aug 31, 2025 with a price of $169

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Buffalo, NY, as early as possible.

You can expect to pay from $169 to $170 for a bus ticket from Florence, SC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $169 which is on 2025-08-31.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Buffalo but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Florence to Buffalo.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Florence to Buffalo.

Tune out to the fine sounds of your best music playlist on your bus trip from Florence to Buffalo while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from Florence, SC, US to Buffalo, NY?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Florence, SC, US by bus?

Bus from Buffalo, NY to Florence, SC, US

You can also go to Buffalo, NY by train

Train from Florence, SC, US to Buffalo, NY

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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