Find coaches from Indianapolis to Greenville, SC

Next departures

Next departures from Indianapolis to Greenville on 3 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Downtown Transit Center
1116 Woodruff RdCheapest
Greyhound Lines, Inc.
Indianapolis Bus Station
1116 Woodruff RdFastest
Greyhound Lines, Inc. + FlixBus
Indianapolis Bus Station
1116 Woodruff RdNo tags
Greyhound Lines, Inc.
Indianapolis Bus Station
1116 Woodruff RdNo tags
FlixBus
Downtown Transit Center
1116 Woodruff RdNo tags

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Compare 2 ways to travel from Indianapolis to Greenville

Bus
Average priceUS$70 - US$234Average duration16h 15m
16kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$156 - US$304Average duration1d 5h
58kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 15 minutes and with fares starting at just US$70, it presents an excellent value for a comfortable ride.

6bus per day
16h 15mAverage duration
US$70Cheapest ticket
16kgCO₂ emissions

Bus Indianapolis to Greenville, SC: Trip Overview

Average ticket priceUS$101
Average bus trip duration16h 15m
Number of daily buses6
Earliest bus departure03:35
Distance401 miles
Latest bus departure23:30

Indianapolis to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to Greenville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Indianapolis - Greenville, SC

  1. What's the distance between Indianapolis and Greenville by coach?

    The distance between Indianapolis and Greenville by coach is approximately 398 miles (641 km).

  2. What is the best way to go from Indianapolis to Greenville without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/08
US$91
01/09
No data
Today
No data
03/09
US$75
04/09
No data
05/09
US$82
06/09
No data
07/09
US$84
busbud logoThe cheapest trip from Indianapolis to Greenville, SC was searched and found on 3 Sept 2025 with a price of US$75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC as early as possible.

You can expect to pay from US$75 to US$129 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$75, which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Greenville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from Indianapolis to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Greenville, SC to Indianapolis

You can also go to Greenville, SC by train

Train from Indianapolis to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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