Bus Tickets from San Diego, CA, US to Chicago

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WedSep 3
from US$243
ThuSep 4
from US$229
FriSep 5
from US$207
SatSep 6
from US$137
SunSep 7
from US$160
MonSep 8
from US$132
TueSep 9
from US$209
WedSep 10

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 4 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 4 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 4 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 4 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: September 7 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 4 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: September 7 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from San Diego to Chicago

Bus
Average PriceUS$106 - US$692Average Duration2d 7h
70kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$175 - US$502Average Duration2d 19h
254kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from San Diego to Chicago

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 2 days, 7 hours 35 minutes, and with fares starting at just US$106, it presents an excellent value for a comfortable ride.

26bus per day
2d 7hAverage Duration
US$106Cheapest ticket
70kgCO₂ emissions

Bus San Diego, CA, US to Chicago: Trip Overview

Average Ticket PriceUS$181
Average Bus Trip Duration2d 7h
Number of daily buses26
Earliest bus departure7:15am
Distance2785 km
Latest bus departure7:35pm

San Diego to Chicago Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Diego to Chicago.

From cheap bus tickets to more luxurious buses travelling from San Diego to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - Chicago

  1. How far is San Diego from Chicago?

    The distance between San Diego and Chicago is approximately 2788 km (1729 miles).

  2. What are the departure and arrival locations for buses traveling from San Diego to Chicago?

    Buses departing from Mission Valley Sheraton in San Diego will take you to Downtown Greyhound Station in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-30
US$254
08-31
US$331
Today
US$293
09-02
US$376
09-03
US$267
09-04
US$282
09-05
US$227
09-06
US$154
busbud logoThe cheapest trip from San Diego, CA, US to Chicago was searched and found on Sep 6, 2025 with a price of US$154

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Chicago, as early as possible.

You can expect to pay from US$154 to US$410 for a bus ticket from San Diego, CA, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$154 which is on 2025-09-06.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Diego to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Diego to Chicago.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Chicago that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Chicago.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from San Diego, CA, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from Chicago to San Diego, CA, US

You can also go to Chicago by train

Train from San Diego, CA, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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