Bus Tickets from Lafayette, IN to Knoxville, TN

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Previously seen trips

One passenger / one way

  • Departure time: September 15 at
    Departure city: Lafayette
    Departure location: Lafayette Bus Stop
    Arrival time: September 16 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 18 at
    Departure city: Lafayette
    Departure location: Lafayette Bus Stop
    Arrival time: September 18 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 18 at
    Departure city: Lafayette
    Departure location: Lafayette Bus Stop
    Arrival time: September 19 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 18 at
    Departure city: Lafayette
    Departure location: Lafayette Bus Stop
    Arrival time: September 19 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: October 20 at
    Departure city: Lafayette
    Departure location: Lafayette Bus Stop
    Arrival time: October 20 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Bus Lafayette, IN to Knoxville, TN: Trip Overview

Average Ticket PriceUS$99
Average Bus Trip Duration22h 45m
Number of daily buses3
Earliest bus departure3:35am
Distance558 km
Latest bus departure11:05pm

Lafayette to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Lafayette to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Lafayette to Knoxville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Lafayette to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Lafayette, IN - Knoxville, TN

  1. What is the distance between Lafayette and Knoxville?

    The distance covered from Lafayette to Knoxville is 557 km (346 miles).

  2. What are the departure and arrival locations for buses traveling from Lafayette to Knoxville?

    Buses traveling this route start their trip at CityBus Center, in Lafayette, and end it at 100 Kirkwood St, in Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-29
US$91
08-30
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09-01
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busbud logoThe cheapest trip from Lafayette, IN to Knoxville, TN was searched and found on Aug 29, 2025 with a price of US$91

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lafayette, IN to Knoxville, TN, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Lafayette to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Lafayette to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Lafayette to Knoxville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Lafayette to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Lafayette, IN by bus?

Bus from Knoxville, TN to Lafayette, IN

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